INBRX-109 is a multivalent agonist of DR5 in Phase 1 clinical development. It was built with the proprietary Inhibrx single domain antibody platform (sdAb). Activation of the DR5 receptor can lead to tumor biased cell death. DR5 activation requires higher-order clustering of receptors to initiate cell death but clustering of too many DR5 receptors can lead to cell death in normal tissues, most notably the liver. INBRX-109 was designed to maximize the therapeutic index of DR5 activation. A tetravalent format, INBRX-109 clusters four receptors and in preclinical studies led to tumor, but not liver, cell death. Preclinical data demonstrated the potential of DR5 activating agents to induce cell death in a variety of tumors with limited treatment options – colorectal adenocarcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma, mesothelioma and certain sarcomas.
About the Inhibrx sdAb Platform
Inhibrx utilizes diverse methods of protein engineering to address the specific requirements of complex target and disease biology. Our sdAb platform is designed to enable the development of therapeutic candidates with unique mechanisms of action and attributes superior to current monoclonal antibody and fusion protein approaches. sdAbs are highly modular and can be combined to create therapeutic candidates with defined valencies and multiple specificities, enabling enhanced cell signaling and conditional activation. Inhibrx’s sdAb-based therapeutic candidates are manufactured by established processes used to produce therapeutic proteins.
Initially, Inhibrx is utilizing its sdAb platform to pursue therapeutic candidates directed to validated targets, which the Company believes its protein engineering technologies can overcome prior therapeutic limitations.
About Inhibrx, Inc.
Inhibrx is a clinical-stage biotechnology company focused on developing a broad pipeline of novel biologic therapeutic candidates. Inhibrx utilizes diverse methods of protein engineering to therapeutically address the specific requirements of complex target and disease biology, including its proprietary sdAb platform. The Inhibrx pipeline is currently focused on oncology and orphan diseases. Inhibrx has collaborations with bluebird bio, Celgene and Chiesi. For more information, please visit www.inhibrx.com.